I am working in the field of Drug Discovery and Development. My research area is related to discovery of Antiviral and Anticancer drugs from Natural sources. I am also working in the field of Analytical and Bio-analytical Chemistry.
Indian Council of Agricultural Research:
Principal Investigator, Indian Council of Agricultural Research – Agricultural Engineering Division (Extramural Research Project) on “Evaluation of Antiviral and Anticancer potentials of Lac exudate/dye.” (Rs. 22,43,000/-)
BIT Mesra Seed Money Scheme:
Principal Investigator, SMS Project on “Development of Anticancer Formulations from lac based on in-vitro studies on selected Cancer cell lines.” (Rs. 55,000/- + 25,000/- = Rs. 80,000/-)
University Grants Commission:
Principal Investigator, UGC Sponsored Project on “Estimation of Heavy Metals Toxicity in Vegetables & Medicinal Plants collected from Road Side Market and Organized Market Sites of different areas of Ranchi City” (Rs. 80,000/-)
Co-Investigator, UGC Sponsored Research Project on “Formulation Development and Evaluation of Antiviral Drugs” (Rs. 80,000/-)
Prof. (Dr.) B. N. Sinha’s Group – Birla Institute of Technology, Mesra, Ranchi, India:
Our active domains of research are focused towards Lead generation from Synthetic and Natural sources followed by synthesis of potent molecules, their characterization, and biological activities.
At present our group is having two collaborative projects with a German Professor and a French Scientist, working for Antivirals, involved in design and synthesis of inhibitors for Dengue and Chikungunya viral infections, funded by DBT (Govt. of India and BMBF).
- Synthetic approach: Our molecular modeling group actively engaged in rational design of ligands through Structure-Based Drug Design (SBDD) and LIGAND BASED DRUG DESIGN (LBDD). The HITs obtained through in-silico studies are synthesized by our synthetic medicinal group. We are engaged in developing our laboratory for carrying out certain in-vitro screenings as well. We have collaboration with eminent biologists around the world for screening our molecules. We participate in exchanging our views, ideas, thoughts and critical discussion with our collaborators to deliver a quality research output.
- Phytochemical approach: Plant materials, claimed to have a particular activity (reviewed through ancient and modern literature) are subjected to usual extraction, isolation of phytoconstituents followed by their characterization to generate a lead. It is modeled and docked against the specified target to propose a few novel analogues, to be synthesized in wet lab.
Prof. (Dr.) Julio A. Seijas’s Group (GI-1599 – New Synthetic Methodologies) – University of Santiago de Compostela, Lugo, Spain:
- Microwave Assisted Organic Synthesis (MAOS)
- Isolation, structural elucidation and synthesis of natural products
- Development of new eco-friendly synthetic methodologies (Green Chemistry)
Prof. (Dr.) David Lembo’s Group – University of Turin, Orbassano (Turin), Italy:
- Antiviral studies on Synthetic and Natural products